Srinivasan, S. Aging and Diet: To choose or not to choose. Elife. 2021;10:e66755.
Littlejohn NK, Seban N, Liu CC, Srinivasan S. A feedback loop governs the relationship between lipid metabolism and longevity. Elife. 2020 Oct 20;9. doi: 10.7554/eLife.58815. PubMed PMID: 33078707; PubMed Central PMCID: PMC7575325.
Srinivasan S. Neuroendocrine control of lipid metabolism: lessons from C. elegans. J Neurogenet. 2020 Jul 3;:1-7. doi: 10.1080/01677063.2020.1777116. [Epub ahead of print] PubMed PMID: 32619378; NIHMSID:NIHMS1647413.
Bouagnon AD, Lin L, Srivastava S, Liu CC, Panda O, Schroeder FC, Srinivasan S, Ashrafi K. Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism. PLoS Biol. 2019 Dec;17(12):e3000242. doi: 10.1371/journal.pbio.3000242. eCollection 2019 Dec. PubMed PMID: 31805041; PubMed Central PMCID: PMC6917301.
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4. PubMed PMID: 30527540; PubMed Central PMCID: PMC6408259.
Kok BP, Galmozzi A, Littlejohn NK, Albert V, Godio C, Kim W, Kim SM, Bland JS, Grayson N, Fang M, Meyerhof W, Siuzdak G, Srinivasan S, Behrens M, Saez E. Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits. Mol Metab. 2018 Oct;16:76-87. doi: 10.1016/j.molmet.2018.07.013. Epub 2018 Aug 4. PubMed PMID: 30120064; PubMed Central PMCID: PMC6158035.
Hussey R, Littlejohn NK, Witham E, Vanstrum E, Mesgarzadeh J, Ratanpal H, Srinivasan S. Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans. PLoS Genet. 2018 Mar;14(3):e1007305. doi: 10.1371/journal.pgen.1007305. eCollection 2018 Mar. PubMed PMID: 29579048; PubMed Central PMCID: PMC5886693.
Hussey R, Stieglitz J, Mesgarzadeh J, Locke TT, Zhang YK, Schroeder FC, Srinivasan S. Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans. PLoS Genet. 2017 May;13(5):e1006806. doi: 10.1371/journal.pgen.1006806. eCollection 2017 May. PubMed PMID: 28545126; PubMed Central PMCID: PMC5456406.
Palamiuc L, Noble T, Witham E, Ratanpal H, Vaughan M, Srinivasan S. A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism. Nat Commun. 2017 Jan 27;8:14237. doi: 10.1038/ncomms14237. PubMed PMID: 28128367; PubMed Central PMCID: PMC5290170.
Witham E, Comunian C, Ratanpal H, Skora S, Zimmer M, Srinivasan S. C. elegans Body Cavity Neurons Are Homeostatic Sensors that Integrate Fluctuations in Oxygen Availability and Internal Nutrient Reserves. Cell Rep. 2016 Feb 23;14(7):1641-1654. doi: 10.1016/j.celrep.2016.01.052. Epub 2016 Feb 11. PubMed PMID: 26876168; PubMed Central PMCID: PMC4767172.
Srinivasan S. Regulation of body fat in Caenorhabditis elegans. Annu Rev Physiol. 2015;77:161-78. doi: 10.1146/annurev-physiol-021014-071704. Epub 2014 Oct 20. Review. PubMed PMID: 25340962; PubMed Central PMCID: PMC4766980.
Noble T, Stieglitz J, Srinivasan S. An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat. Cell Metab. 2013 Nov 5;18(5):672-84. doi: 10.1016/j.cmet.2013.09.007. Epub 2013 Oct 10. PubMed PMID: 24120942; PubMed Central PMCID: PMC3882029.
Behl M, Rao D, Aagaard K, Davidson TL, Levin ED, Slotkin TA, Srinivasan S, Wallinga D, White MF, Walker VR, Thayer KA, Holloway AC. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environ Health Perspect. 2013 Feb;121(2):170-80. doi: 10.1289/ehp.1205404. Epub 2012 Dec 11. Review. PubMed PMID: 23232494; PubMed Central PMCID: PMC3569686.
Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metab. 2012 Jul 3;16(1):113-21. doi: 10.1016/j.cmet.2012.05.014. PubMed PMID: 22768843; PubMed Central PMCID: PMC3413480.
Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biol. 2011 Dec;9(12):e1001219. doi: 10.1371/journal.pbio.1001219. Epub 2011 Dec 13. PubMed PMID: 22180729; PubMed Central PMCID: PMC3236739.
Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug;5(8):673-8. doi: 10.1038/nmeth.1232. Review. PubMed PMID: 18668035; PubMed Central PMCID: PMC2703467.
Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab. 2008 Jun;7(6):533-44. doi: 10.1016/j.cmet.2008.04.012. PubMed PMID: 18522834; PubMed Central PMCID: PMC2495008.
Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007 Aug 1;2(7):e668. doi: 10.1371/journal.pone.0000668. PubMed PMID: 17668051; PubMed Central PMCID: PMC1930153.
Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides. 2005 Oct;26(10):1909-19. doi: 10.1016/j.peptides.2004.11.042. Review. PubMed PMID: 16083993; NIHMSID:NIHMS537196.
Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest. 2004 Oct;114(8):1158-64. doi: 10.1172/JCI21927. PubMed PMID: 15489963; PubMed Central PMCID: PMC522250.
Alexander S, Srinivasan S, Alexander H. Proteomics opens doors to the mechanisms of developmentally regulated secretion. Mol Cell Proteomics. 2003 Nov;2(11):1156-63. doi: 10.1074/mcp.R300011-MCP200. Epub 2003 Sep 22. Review. PubMed PMID: 14504294.
Srinivasan S, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann N Y Acad Sci. 2003 Jun;994:225-32. doi: 10.1111/j.1749-6632.2003.tb03184.x. Review. PubMed PMID: 12851320; NIHMSID:NIHMS537202.
Srinivasan S, Traini M, Herbert B, Sexton D, Harry J, Alexander H, Williams KL, Alexander S. Proteomic analysis of a developmentally regulated secretory vesicle. Proteomics. 2001 Sep;1(9):1119-27. doi: 10.1002/1615-9861(200109)1:9<1119::AID-PROT1119>3.0.CO;2-X. PubMed PMID: 11990506.
Srinivasan S, Griffiths KR, McGuire V, Champion A, Williams KL, Alexander S. The cellulose-binding activity of the PsB multiprotein complex is required for proper assembly of the spore coat and spore viability in Dictyostelium discoideum. Microbiology (Reading). 2000 Aug;146 ( Pt 8):1829-1839. doi: 10.1099/00221287-146-8-1829. PubMed PMID: 10931888.
Srinivasan S, Alexander H, Alexander S. Crossing the finish line of development: regulated secretion of Dictyostelium proteins. Trends Cell Biol. 2000 Jun;10(6):215-9. doi: 10.1016/s0962-8924(00)01758-x. Review. PubMed PMID: 10802536.
Mreyen M, Champion A, Srinivasan S, Karuso P, Williams KL, Packer NH. Multiple O-glycoforms on the spore coat protein SP96 in Dictyostelium discoideum. Fuc(alpha1-3)GlcNAc-alpha-1-P-Ser is the major modification. J Biol Chem. 2000 Apr 21;275(16):12164-74. doi: 10.1074/jbc.275.16.12164. PubMed PMID: 10766852.
Srinivasan S, Alexander H, Alexander S. The Dictyostelium fruiting body--A structure of cells and cellulose. Trends in cell biology. 2000; (10):315.
Srinivasan S, Alexander H, Alexander S. The prespore vesicles of Dictyostelium discoideum. Purification, characterization, and developmental regulation. J Biol Chem. 1999 Dec 10;274(50):35823-31. doi: 10.1074/jbc.274.50.35823. PubMed PMID: 10585466.